Renal Handling of Ammonium and Acid Base Regulation
نویسندگان
چکیده
منابع مشابه
Renal Handling of Ammonium and Acid Base Regulation
Renal ammonium metabolism is the primary component of net acid excretion and thereby is critical for acid-base homeostasis. Briefly, ammonium is produced from glutamine in the proximal tubule in a series of biochemical reactions that result in equimolar bicarbonate. Ammonium is predominantly secreted into the luminal fluid via the apical Na(+)/H(+) exchanger, NHE3. The thick ascending limb of t...
متن کاملAltered Regulation of Renal Acid Base Transporters in Response to Ammonium Chloride Loading in Rats
The role of the kidney in combating metabolic acidosis has been a subject of considerable interest for many years. The present study was aimed to determine whether there is an altered regulation of renal acid base transporters in acute and chronic acid loading. Male Sprague-Dawley rats were used. Metabolic acidosis was induced by administration of NH(4)Cl for 2 days (acute) and for 7days (chron...
متن کاملRenal Regulation of Acid-base Balance
T his article reviews the role of the kidneys in the regulation of acid-base balance. It is intended as a guide for those who teach this aspect of renal physiology to health professions students. An approach is described, which begins with an overview of acid-base balance and then proceeds to describe the details of renal H1 transport and the important role the production and excretion of NH4 1...
متن کاملRenal regulation of acid-base balance.
Because maintaining a normal body pH is essential to the efficient functioning of many physiologic processes, the body has a number of mechanisms that prevent pH fluctuations. Some of these prevent minute-to-minute pH fluctuations over the course of the day, whereas others maintain pH balance from day to day. The kidney plays a key role in both processes. The renal process of bicarbonate reclam...
متن کاملBicarbonate and the Renal Regulation of Acid Base Balance1
Under the usual circumstance of ingestion of an acid ash diet the normal individual is faced with a deficit of available base. Those stores of circulating bicarbonate which enter the glomerular filtrate along with other crystalloids of the plasma are carefully conserved; only minute amounts are lost in the urine. But when an alkaline ash diet is ingested or sodium bicarbonate is administered, s...
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ژورنال
عنوان ژورنال: Electrolytes & Blood Pressure
سال: 2009
ISSN: 1738-5997
DOI: 10.5049/ebp.2009.7.1.9